Exploration
Accueil
Racine
Exploration
Accueil

Corpus GrippeBresilV1

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Laxative effects and mechanism of action of Brazilian green propolis.

Identifieur interne : 000149 ( Main/Exploration ); précédent : 000148; suivant : 000150

Laxative effects and mechanism of action of Brazilian green propolis.

Auteurs : Mamoru Kakino [Japon] ; Hiroshi Izuta ; Kazuhiro Tsuruma ; Yoko Araki ; Masamitsu Shimazawa ; Kenji Ichihara ; Hideaki Hara

Source :

RBID : pubmed:23088672

Descripteurs français

English descriptors

Abstract

BACKGROUND

Brazilian green propolis is reported to have wide range of biological properties including antibacterial, anti-inflammatory, anti-influenza, and antioxidant activities. In the digestive system, a protective effect of propolis on gastric ulcer has been reported, but a laxative effect has not yet been reported. We investigated the effect and the mechanism of action of water and ethanol extracts of Brazilian green propolis.

METHODS

We examined the laxative effect of propolis on stool frequency by administering orally an ethanol extract of propolis (EEP) or a water extract of propolis (WEP) at 10, 50, 100, or 500 mg/kg to normal mice. We then investigated the effects of propolis using constipation model mice induced by two types of drugs, loperamide (a μ opioid receptor agonist) and clonidine (an α-2 adrenergic receptor agonist). We also investigated the effects of WEP on gastrointestinal transit and contractional tension of the ileum to uncover the mechanism of action of WEP.

RESULTS

Treatment with WEP, but not with EEP, significantly increased the weight of stools (p<0.01 at 500 mg/kg). WEP treatment significantly restored stool frequency and stool weight in clonidine-induced constipation model mice, but not in loperamide-induced constipation model mice. WEP treatment did not affect gastro-intestinal transit, but significantly increased the contractional tension of the isolated ileum of guinea pigs. This increase was inhibited by an acetylcholine receptor antagonist (atropine), but not by a 5-HT receptor antagonist (GR113808).

CONCLUSION

These findings indicate that WEP has laxative effects both in normal mice and in clonidine-induced constipation model mice. The laxative effects of WEP might be mediated by increased contractional tension of the ileum exerted at least in part via activation of an acetylcholine receptor.


DOI: 10.1186/1472-6882-12-192
PubMed: 23088672


Affiliations:

Links toward previous steps (curation, corpus...)

Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Laxative effects and mechanism of action of Brazilian green propolis.</title>
<author>
<name sortKey="Kakino, Mamoru" sort="Kakino, Mamoru" uniqKey="Kakino M" first="Mamoru" last="Kakino">Mamoru Kakino</name>
<affiliation wicri:level="1">
<nlm:affiliation>Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196</wicri:regionArea>
<wicri:noRegion>Gifu 501-1196</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Izuta, Hiroshi" sort="Izuta, Hiroshi" uniqKey="Izuta H" first="Hiroshi" last="Izuta">Hiroshi Izuta</name>
</author>
<author>
<name sortKey="Tsuruma, Kazuhiro" sort="Tsuruma, Kazuhiro" uniqKey="Tsuruma K" first="Kazuhiro" last="Tsuruma">Kazuhiro Tsuruma</name>
</author>
<author>
<name sortKey="Araki, Yoko" sort="Araki, Yoko" uniqKey="Araki Y" first="Yoko" last="Araki">Yoko Araki</name>
</author>
<author>
<name sortKey="Shimazawa, Masamitsu" sort="Shimazawa, Masamitsu" uniqKey="Shimazawa M" first="Masamitsu" last="Shimazawa">Masamitsu Shimazawa</name>
</author>
<author>
<name sortKey="Ichihara, Kenji" sort="Ichihara, Kenji" uniqKey="Ichihara K" first="Kenji" last="Ichihara">Kenji Ichihara</name>
</author>
<author>
<name sortKey="Hara, Hideaki" sort="Hara, Hideaki" uniqKey="Hara H" first="Hideaki" last="Hara">Hideaki Hara</name>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PubMed</idno>
<date when="2012">2012</date>
<idno type="RBID">pubmed:23088672</idno>
<idno type="pmid">23088672</idno>
<idno type="doi">10.1186/1472-6882-12-192</idno>
<idno type="wicri:Area/Main/Corpus">000177</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000177</idno>
<idno type="wicri:Area/Main/Curation">000177</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000177</idno>
<idno type="wicri:Area/Main/Exploration">000177</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en">Laxative effects and mechanism of action of Brazilian green propolis.</title>
<author>
<name sortKey="Kakino, Mamoru" sort="Kakino, Mamoru" uniqKey="Kakino M" first="Mamoru" last="Kakino">Mamoru Kakino</name>
<affiliation wicri:level="1">
<nlm:affiliation>Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196</wicri:regionArea>
<wicri:noRegion>Gifu 501-1196</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Izuta, Hiroshi" sort="Izuta, Hiroshi" uniqKey="Izuta H" first="Hiroshi" last="Izuta">Hiroshi Izuta</name>
</author>
<author>
<name sortKey="Tsuruma, Kazuhiro" sort="Tsuruma, Kazuhiro" uniqKey="Tsuruma K" first="Kazuhiro" last="Tsuruma">Kazuhiro Tsuruma</name>
</author>
<author>
<name sortKey="Araki, Yoko" sort="Araki, Yoko" uniqKey="Araki Y" first="Yoko" last="Araki">Yoko Araki</name>
</author>
<author>
<name sortKey="Shimazawa, Masamitsu" sort="Shimazawa, Masamitsu" uniqKey="Shimazawa M" first="Masamitsu" last="Shimazawa">Masamitsu Shimazawa</name>
</author>
<author>
<name sortKey="Ichihara, Kenji" sort="Ichihara, Kenji" uniqKey="Ichihara K" first="Kenji" last="Ichihara">Kenji Ichihara</name>
</author>
<author>
<name sortKey="Hara, Hideaki" sort="Hara, Hideaki" uniqKey="Hara H" first="Hideaki" last="Hara">Hideaki Hara</name>
</author>
</analytic>
<series>
<title level="j">BMC complementary and alternative medicine</title>
<idno type="eISSN">1472-6882</idno>
<imprint>
<date when="2012" type="published">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Animals</term>
<term>Bees</term>
<term>Brazil</term>
<term>Constipation (drug therapy)</term>
<term>Constipation (physiopathology)</term>
<term>Gastrointestinal Transit (drug effects)</term>
<term>Guinea Pigs</term>
<term>Humans</term>
<term>Laxatives (administration & dosage)</term>
<term>Male</term>
<term>Mice</term>
<term>Propolis (administration & dosage)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Abeilles</term>
<term>Animaux</term>
<term>Brésil</term>
<term>Cochons d'Inde</term>
<term>Constipation (physiopathologie)</term>
<term>Constipation (traitement médicamenteux)</term>
<term>Humains</term>
<term>Laxatifs (administration et posologie)</term>
<term>Mâle</term>
<term>Propolis (administration et posologie)</term>
<term>Souris</term>
<term>Transit gastrointestinal ()</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en">
<term>Laxatives</term>
<term>Propolis</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en">
<term>Brazil</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr">
<term>Laxatifs</term>
<term>Propolis</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en">
<term>Gastrointestinal Transit</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en">
<term>Constipation</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr">
<term>Constipation</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en">
<term>Constipation</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr">
<term>Constipation</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Animals</term>
<term>Bees</term>
<term>Guinea Pigs</term>
<term>Humans</term>
<term>Male</term>
<term>Mice</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Abeilles</term>
<term>Animaux</term>
<term>Brésil</term>
<term>Cochons d'Inde</term>
<term>Humains</term>
<term>Mâle</term>
<term>Souris</term>
<term>Transit gastrointestinal</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr">
<term>Brésil</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<p>
<b>BACKGROUND</b>
</p>
<p>Brazilian green propolis is reported to have wide range of biological properties including antibacterial, anti-inflammatory, anti-influenza, and antioxidant activities. In the digestive system, a protective effect of propolis on gastric ulcer has been reported, but a laxative effect has not yet been reported. We investigated the effect and the mechanism of action of water and ethanol extracts of Brazilian green propolis.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>METHODS</b>
</p>
<p>We examined the laxative effect of propolis on stool frequency by administering orally an ethanol extract of propolis (EEP) or a water extract of propolis (WEP) at 10, 50, 100, or 500 mg/kg to normal mice. We then investigated the effects of propolis using constipation model mice induced by two types of drugs, loperamide (a μ opioid receptor agonist) and clonidine (an α-2 adrenergic receptor agonist). We also investigated the effects of WEP on gastrointestinal transit and contractional tension of the ileum to uncover the mechanism of action of WEP.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>RESULTS</b>
</p>
<p>Treatment with WEP, but not with EEP, significantly increased the weight of stools (p<0.01 at 500 mg/kg). WEP treatment significantly restored stool frequency and stool weight in clonidine-induced constipation model mice, but not in loperamide-induced constipation model mice. WEP treatment did not affect gastro-intestinal transit, but significantly increased the contractional tension of the isolated ileum of guinea pigs. This increase was inhibited by an acetylcholine receptor antagonist (atropine), but not by a 5-HT receptor antagonist (GR113808).</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>CONCLUSION</b>
</p>
<p>These findings indicate that WEP has laxative effects both in normal mice and in clonidine-induced constipation model mice. The laxative effects of WEP might be mediated by increased contractional tension of the ileum exerted at least in part via activation of an acetylcholine receptor.</p>
</div>
</front>
</TEI>
<pubmed>
<MedlineCitation Status="MEDLINE" Owner="NLM">
<PMID Version="1">23088672</PMID>
<DateCompleted>
<Year>2013</Year>
<Month>02</Month>
<Day>06</Day>
</DateCompleted>
<DateRevised>
<Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Electronic">
<Journal>
<ISSN IssnType="Electronic">1472-6882</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>12</Volume>
<PubDate>
<Year>2012</Year>
<Month>Oct</Month>
<Day>22</Day>
</PubDate>
</JournalIssue>
<Title>BMC complementary and alternative medicine</Title>
<ISOAbbreviation>BMC Complement Altern Med</ISOAbbreviation>
</Journal>
<ArticleTitle>Laxative effects and mechanism of action of Brazilian green propolis.</ArticleTitle>
<Pagination>
<MedlinePgn>192</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1186/1472-6882-12-192</ELocationID>
<Abstract>
<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Brazilian green propolis is reported to have wide range of biological properties including antibacterial, anti-inflammatory, anti-influenza, and antioxidant activities. In the digestive system, a protective effect of propolis on gastric ulcer has been reported, but a laxative effect has not yet been reported. We investigated the effect and the mechanism of action of water and ethanol extracts of Brazilian green propolis.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We examined the laxative effect of propolis on stool frequency by administering orally an ethanol extract of propolis (EEP) or a water extract of propolis (WEP) at 10, 50, 100, or 500 mg/kg to normal mice. We then investigated the effects of propolis using constipation model mice induced by two types of drugs, loperamide (a μ opioid receptor agonist) and clonidine (an α-2 adrenergic receptor agonist). We also investigated the effects of WEP on gastrointestinal transit and contractional tension of the ileum to uncover the mechanism of action of WEP.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Treatment with WEP, but not with EEP, significantly increased the weight of stools (p<0.01 at 500 mg/kg). WEP treatment significantly restored stool frequency and stool weight in clonidine-induced constipation model mice, but not in loperamide-induced constipation model mice. WEP treatment did not affect gastro-intestinal transit, but significantly increased the contractional tension of the isolated ileum of guinea pigs. This increase was inhibited by an acetylcholine receptor antagonist (atropine), but not by a 5-HT receptor antagonist (GR113808).</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">These findings indicate that WEP has laxative effects both in normal mice and in clonidine-induced constipation model mice. The laxative effects of WEP might be mediated by increased contractional tension of the ileum exerted at least in part via activation of an acetylcholine receptor.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y">
<Author ValidYN="Y">
<LastName>Kakino</LastName>
<ForeName>Mamoru</ForeName>
<Initials>M</Initials>
<AffiliationInfo>
<Affiliation>Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Izuta</LastName>
<ForeName>Hiroshi</ForeName>
<Initials>H</Initials>
</Author>
<Author ValidYN="Y">
<LastName>Tsuruma</LastName>
<ForeName>Kazuhiro</ForeName>
<Initials>K</Initials>
</Author>
<Author ValidYN="Y">
<LastName>Araki</LastName>
<ForeName>Yoko</ForeName>
<Initials>Y</Initials>
</Author>
<Author ValidYN="Y">
<LastName>Shimazawa</LastName>
<ForeName>Masamitsu</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y">
<LastName>Ichihara</LastName>
<ForeName>Kenji</ForeName>
<Initials>K</Initials>
</Author>
<Author ValidYN="Y">
<LastName>Hara</LastName>
<ForeName>Hideaki</ForeName>
<Initials>H</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList>
<PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic">
<Year>2012</Year>
<Month>10</Month>
<Day>22</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo>
<Country>England</Country>
<MedlineTA>BMC Complement Altern Med</MedlineTA>
<NlmUniqueID>101088661</NlmUniqueID>
<ISSNLinking>1472-6882</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList>
<Chemical>
<RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D054368">Laxatives</NameOfSubstance>
</Chemical>
<Chemical>
<RegistryNumber>9009-62-5</RegistryNumber>
<NameOfSubstance UI="D011429">Propolis</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList>
<MeshHeading>
<DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D001516" MajorTopicYN="N">Bees</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D001938" MajorTopicYN="N" Type="Geographic">Brazil</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D003248" MajorTopicYN="N">Constipation</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D005772" MajorTopicYN="N">Gastrointestinal Transit</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D006168" MajorTopicYN="N">Guinea Pigs</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D054368" MajorTopicYN="N">Laxatives</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D011429" MajorTopicYN="N">Propolis</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData>
<History>
<PubMedPubDate PubStatus="received">
<Year>2012</Year>
<Month>01</Month>
<Day>16</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted">
<Year>2012</Year>
<Month>10</Month>
<Day>17</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez">
<Year>2012</Year>
<Month>10</Month>
<Day>24</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed">
<Year>2012</Year>
<Month>10</Month>
<Day>24</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline">
<Year>2013</Year>
<Month>2</Month>
<Day>7</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>epublish</PublicationStatus>
<ArticleIdList>
<ArticleId IdType="pubmed">23088672</ArticleId>
<ArticleId IdType="pii">1472-6882-12-192</ArticleId>
<ArticleId IdType="doi">10.1186/1472-6882-12-192</ArticleId>
<ArticleId IdType="pmc">PMC3487869</ArticleId>
</ArticleIdList>
<ReferenceList>
<Reference>
<Citation>Evid Based Complement Alternat Med. 2012;2012:946867</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21876716</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Z Naturforsch C. 1999 May-Jun;54(5-6):401-5</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">10431391</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Ethnopharmacol. 2005 Aug 22;100(1-2):114-7</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">15993016</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Biosci Biotechnol Biochem. 2010;74(8):1550-5</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20699592</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Ethnopharmacol. 2005 May 13;99(1):5-11</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">15848013</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Am Board Fam Med. 2011 Jul-Aug;24(4):436-51</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21737769</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Planta Med. 2006 Aug;72(10):899-906</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">16902858</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Biol Pharm Bull. 2005 Oct;28(10):1909-14</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">16204944</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Chest. 1983 Feb;83(2 Suppl):296-9</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">6129945</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Phytother Res. 2001 Nov;15(7):561-71</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">11746834</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Can J Comp Med. 1972 Oct;36(4):319-28</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">4263909</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Z Naturforsch C. 2002 Mar-Apr;57(3-4):372-8</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">12064743</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Biol Pharm Bull. 2009 Dec;32(12):2022-8</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19952422</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Aliment Pharmacol Ther. 2001 Sep;15(9):1239-52</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">11552894</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>BMC Complement Altern Med. 2009;9:4</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19243635</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Evid Based Complement Alternat Med. 2011;2011:254914</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21423687</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Evid Based Complement Alternat Med. 2005 Mar;2(1):33-38</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">15841276</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Clin Exp Pharmacol Physiol. 2004 Dec;31 Suppl 2:S29-30</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">15649281</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Agric Food Chem. 2002 Apr 24;50(9):2502-6</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">11958612</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Z Naturforsch C. 1996 May-Jun;51(5-6):277-80</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">8663896</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Evid Based Complement Alternat Med. 2005 Mar;2(1):85-92</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">15841282</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Antivir Chem Chemother. 2008;19(1):7-13</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18610553</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Food Chem Toxicol. 1998 Apr;36(4):347-63</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">9651052</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Nat Prod Res. 2012;26(4):331-43</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21432718</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>PLoS One. 2008;3(10):e3348</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18833323</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Life Sci. 2007 Jan 2;80(4):370-7</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">17046025</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Biol Pharm Bull. 2009 Jul;32(7):1244-50</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19571393</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Experientia. 1988 Mar 15;44(3):230-2</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">2450776</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Biol Pharm Bull. 2004 Nov;27(11):1797-803</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">15516726</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Pharmacol Exp Ther. 1991 Sep;258(3):790-6</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">1679848</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Pharmacol Toxicol. 1987 Aug;61(2):153-6</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">3671329</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Anticancer Res. 1996 Sep-Oct;16(5A):2669-72</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">8917367</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Braz J Biol. 2011 Aug;71(3):727-34</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21881797</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Phytother Res. 2009 Oct;23(10):1431-8</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19277960</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Evid Based Complement Alternat Med. 2005 Mar;2(1):29-32</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">15841275</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations>
<list>
<country>
<li>Japon</li>
</country>
</list>
<tree>
<noCountry>
<name sortKey="Araki, Yoko" sort="Araki, Yoko" uniqKey="Araki Y" first="Yoko" last="Araki">Yoko Araki</name>
<name sortKey="Hara, Hideaki" sort="Hara, Hideaki" uniqKey="Hara H" first="Hideaki" last="Hara">Hideaki Hara</name>
<name sortKey="Ichihara, Kenji" sort="Ichihara, Kenji" uniqKey="Ichihara K" first="Kenji" last="Ichihara">Kenji Ichihara</name>
<name sortKey="Izuta, Hiroshi" sort="Izuta, Hiroshi" uniqKey="Izuta H" first="Hiroshi" last="Izuta">Hiroshi Izuta</name>
<name sortKey="Shimazawa, Masamitsu" sort="Shimazawa, Masamitsu" uniqKey="Shimazawa M" first="Masamitsu" last="Shimazawa">Masamitsu Shimazawa</name>
<name sortKey="Tsuruma, Kazuhiro" sort="Tsuruma, Kazuhiro" uniqKey="Tsuruma K" first="Kazuhiro" last="Tsuruma">Kazuhiro Tsuruma</name>
</noCountry>
<country name="Japon">
<noRegion>
<name sortKey="Kakino, Mamoru" sort="Kakino, Mamoru" uniqKey="Kakino M" first="Mamoru" last="Kakino">Mamoru Kakino</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/GrippeBresilV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000149 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000149 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    GrippeBresilV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:23088672
   |texte=   Laxative effects and mechanism of action of Brazilian green propolis.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:23088672" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a GrippeBresilV1
Wicri

This area was generated with Dilib version V0.6.35.
Data generation: Thu Jul 9 17:25:49 2020. Site generation: Sat Sep 26 10:03:30 2020